At Oregon’s Allison Inn & Spa, you can wake up to a view of Willamette Valley from your terrace, spend the afternoon sampling Pinot Noirs at local wineries, then retreat to the hotel spa for a “pinotherapy” treatment.

That kind of immersive experience has earned Allison Inn the No. 4 ranking among wine country hotels, based on Travel + Leisure readers’ votes in the annual World’s Best Awards survey. The winners come in lots of varietals, from opulent hotels to cozy inns, and turn up in established wine regions (South Africa’s Franschhoek, Argentina’s Mendoza) and less-expected destinations like ...